My life with dialysis and kidney disease
Archive for May, 2006
“So many social engagements, so little time.”
May 19th
I had planned on writing today about several things which have been on my mind recently, but as luck would have it within 1 hour of attaching myself to the dialysis machine, I have already completely forgotten how to think, and I am rapidly approaching no man’s land.
You will notice that the site design has changed AGAIN.
I don’t know what happens to me, I just see something that I want to change – a color, or graphic – and suddenly the whole site is being re-born.
I apologize for this lack of consistency — deal with it.
Wow, I started writing this almost an hour ago. Awesome how great my brain works while I sit plastered to this vinyl sweat-factory.
So – the title of this post
If you don’t know what it’s in reference to, you obviously weren’t watching Nicholas Cage / Holly Hunter movies in 1987.
If you do know what it’s from – congratulations
If your inner voice already responded to the post title with something like: “I’ll pitch my voice where’er I please” or “Work’s what’s kept us happy…”double congratulations, you’re one of the few who understands what makes a movie great.
And finally, if you just stood out of your chair, and pretended to scratch your knuckles on the ceiling whilst preparing to hammer down on someone – you have just received the powerup, and have automatically won the game (you know who you are).
Can Stem Cells Repair Kidneys?
May 1st
From HealthDay News compliments of Dale’s dialysis_support list:
FRIDAY, April 28 (HealthDay News) – U.S. scientists say they’ve used bone marrow-derived stem cells to reverse genetic kidney disease in mice.
Reporting in this week’s Proceedings of the National Academy of Sciences, the team said the stem cells were able to regenerate damaged renal cells in a mouse model of Alport syndrome, the second most common genetic cause of kidney failure in humans.
Symptoms of Alport syndrome usually appear in childhood, and the disease typically results in end-stage renal failure by the time a patient reaches the teens, 20s or 30s.
The study offers the first example of how stem cells may prove useful in repairing defects and restoring organ function and also provides a potential new strategy for treating Alport syndrome.
“This is one of 31 human diseases that occur because of genetic defects in the body’s extracellular matrix and basement membrane proteins,” study senior author Raghu Kalluri, chief of the division of matrix biology at Beth Israel Deaconess Medical Center and associate professor of medicine at Harvard Medical School, explained in a prepared statement.
The extracellular matrix (ECM) is present throughout the body and is made of collagens, proteogylcans, noncollagenous glycoproteins and, in some tissues, elastin fibers. The ECM helps maintain the structural integrity of many tissues by constructing a “scaffold” for cells.
“In normal kidneys, a specialized form of extracellular matrix known as the glomerular basement membrane (GBM), composed primarily of type IV collagen, is the key component of the blood filtration apparatus,” Kalluri said.
Genetic mutations in people with Alport syndrome cause structural damage to the GBM, which results in a breakdown of the kidneys’ filtration system. There is no cure for Alport syndrome. Kidney transplantation or lifelong dialysis are the only treatment options.
About four weeks after the bone marrow-derived stem cells had been transplanted into the mice, about 10 percent of the cells had incorporated into damaged areas of the kidneys and emerged as healthy renal cells. This resulted in improvements in kidney function and repair to GBM damage.
More information
The U.S. National Library of Medicine has more about Alport syndrome.
Wow! This is some exciting news for sure. So perhaps in 17 years after enough R&D this will be usable – but of course by then nano-machines will be building fresh kidneys for everyone from their own genetic material anyway.
OK, I’m not for sure on the second part of that – or the first part for that matter.
This is one of those pieces of news that keeps some of us going. The thought that everything we think we know about medicine is about to change. I know that many patients (myself included) think: “Just endure until you get a transplant, and then by the time you need dialysis again in 20 or 30 (or 2) years everything will be totally different!”
While I know that these things take quite awhile to come to market, I do firmly believe that medicine as we know it will be very different in the not-to-distant future.
Anyone have any other really cool stem-cell research to toss my way?
